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蟾毒靈

分析標(biāo)準(zhǔn)品,HPLC≥98%

Bufalin

CAS號(hào)：465-21-4

分子式： C24H34O4

分子量：386.53

MDL：MFCD00056525

產(chǎn)品介紹

熔點(diǎn)：242-243℃

沸點(diǎn)：556.6 ℃ at 760 mmHg

比旋光度：D -20°

外觀：針狀晶體

溶解性：DMSO  :  100  mg/mL  (258.72  mM;  Need  ultrasonic)

儲(chǔ)存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(33篇)

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32. [IF=5.4] Ruifeng Zeng et al."Tumor-targeted nanosystem with hypoxia inducible factor 1α inhibition for synergistic chemo-photodynamic therapy against hypoxic tumor."COLLOIDS AND SURFACES B-BIOINTERFACES.2024 Dec;:114456

31. [IF=8.2] Tao Li et al."Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway."International Journal of Biological Sciences.2025 Jan;21(1):285

30. [IF=4.8] Hongxuan Yang et al."Huachansu suppresses colorectal cancer via inhibiting PI3K/AKT and glycolysis signaling pathways: Systems biology and network pharmacology."JOURNAL OF ETHNOPHARMACOLOGY.2025 Feb;:119479

29. [IF=8] Qing Zhang et al."MMP-2 Responsive Peptide Hydrogel-Based Nanoplatform for Multimodal Tumor Therapy."International Journal of Nanomedicine.

28. [IF=7.9] Yi-Qing Deng et al."Compound-composed Chinese medicine of Huachansu triggers apoptosis of gastric cancer cells through increase of reactive oxygen species levels and suppression of proteasome activities."PHYTOMEDICINE.2023 Oct;:155169

27. [IF=4.8] Zijun Qian et al."Bufalin inhibits the proliferation of lung cancer cells by suppressing Hippo-YAP pathway."CELLULAR SIGNALLING.2023 Sep;109:110746

26. [IF=1.902] Ke-ke Cui et al."Quantitative analysis of multicomponents by a single marker and quality evaluation of Venenum Bufonis from different geographical origins."Biomed Chromatogr. 2019 Sep;33(9):e4555

25. [IF=3.565] Liqiang Qian et al."Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer."J Cancer. 2020; 11(11): 3114–3123

24. [IF=4.379] Cao  Yueting et al."The impact of multiple climatic and geographic factors on the chemical defences of Asian toads (Bufo gargarizans Cantor)."Sci Rep-Uk. 2019 Nov;9(1):1-11

23. [IF=4.411] Yueting Cao et al."Chemical Profile and Multicomponent Quantitative Analysis for the Quality Evaluation of Toad Venom from Different Origins."Molecules. 2019 Jan;24(19):3595

22. [IF=9.381] Haiyan Hu et al."Albumin coated trimethyl chitosan-based targeting delivery platform for photothermal/chemo-synergistic cancer therapy."Carbohyd Polym. 2020 Aug;241:116335

21. [IF=2.193] Zhang Mei-Tuo et al."Strategic Combination of Isocratic and Gradient Elution for Simultaneous Separation of Polar Compounds in Traditional Chinese Medicines by HPLC."J Anal Methods Chem. 2018;2018:7569283

20. [IF=2.311] Jinlin Xie et al."Bufalin suppresses the proliferation and metastasis of renal cell carcinoma by inhibiting the PI3K/Akt/mTOR signaling pathway."Oncol Lett. 2018 Sep;16(3):3867-3873

19. [IF=2.748] Tao Song et al."Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K+ currents expressed in HEK293 cells."Fund Clin Pharmacol. 2017 Dec;31(6):695-700

18. [IF=2.748] Tao Song et al."Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, inhibits L-type Ca2+ channels and contractility in rat ventricular myocytes."Fund Clin Pharmacol. 2017 Jun;31(3):340-346

17. [IF=3.743] Yu-Long Lan et al."Bufalin inhibits glioblastoma growth by promoting proteasomal degradation of the Na+/K+-ATPase α1 subunit."Biomed Pharmacother. 2018 Jul;103:204

16. [IF=4.101] Yao  Liu et al."Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice."Int J Mol Med. 2017 Aug;40(2):357-366

15. [IF=6.284] Lan  Yu-Long et al."The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway."Cell Biol Toxicol. 2019 Dec;35(6):521-539

14.  Haiyan Hu, Qi Qi, Ziyi Dong, Xianglong Yu, Yujia Mo, Juyuan Luo, Yan Wang, Shouying Du, Yang Lu,

Albumin coated trimethyl chitosan-based targeting delivery platform for photothermal/chemo-synergistic cancer therapy,

Carbohydrate Polymers,

Volume 241,

2020,

13.  Xie, Jinlin, et al. "Bufalin suppresses the proliferation and metastasis of renal cell carcinoma by inhibiting the PI3K/Akt/mTOR signaling pathway." Oncology letters 16.3 (2018): 3867-3873.https:##doi.org/10.3892/ol.2018.9111

12.  Song, Tao, et al. "Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, inhibits L‐type Ca2+ channels and contractility in rat ventricular myocytes." Fundamental & clinical pharmacology 31.3 (2017): 340-346.https:##doi.org/10.1111/fc

11.  Song, Tao, et al. "Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K+ currents expressed in HEK 293 cells." Fundamental & clinical pharmacology 31.6 (2017): 695-700.https:##doi.org/10.1111/fcp.12306

10.  Liu, Yao, et al. "Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice." International journal of molecular medicine 40.2 (2017): 357-366. https:##doi.org/10.3892/ijmm.2017.3039

9.  Liu, Yao, et al. "Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice." International journal of molecular medicine 40.2 (2017): 357-366. https:##doi.org/10.3892/ijmm.2017.3039

8.  曹月婷  崔可可  吳紀(jì)恒 等. 中華大蟾蜍毒液中蟾毒配基類成分的相關(guān)性研究[J]. 中國(guó)中藥雜志  2019(9).

7.  房蘊(yùn)歌, 王鵬飛, 朱厚達(dá),等. 蟾酥藥材和飲片(蟾酥粉)的質(zhì)量標(biāo)準(zhǔn)研究[J]. 中國(guó)中藥雜志, 2020(8).

6.  張妹砣  李玉桑  葉曉雪. 六神丸血漿藥物化學(xué)的研究[J]. 綠色科技  2017  000(012):237-240.

5.  田志輝, 張培, 曹彥坤,等. 蟾蜍靈抑制食管癌細(xì)胞增殖、遷移和趨化運(yùn)動(dòng)的機(jī)制研究[J]. 中國(guó)現(xiàn)代醫(yī)學(xué)雜志, 2015(20):50-54.

4.  丁妍,王小玲,鄧會(huì)巖,蘇麗宏,張培,劉月平.蟾蜍靈抑制Raf/MEK/細(xì)胞外信號(hào)調(diào)節(jié)激酶信號(hào)通路活化影響人食管鱗癌細(xì)胞增殖及遷移機(jī)制研究[J].中國(guó)全科醫(yī)學(xué),2015,18(21):2535-2541.

3.  陳硯凝, 劉堯, 王小玲,等. 蟾蜍令靈對(duì)裸鼠食管鱗癌原位移植瘤中 P70S6K 表達(dá)的影響[J]. 中國(guó)全科醫(yī)學(xué), 2015(15期):1763-1767.

2.  張玲玲  韓金薇  王曉琳  et al. Bufalin抑制食管癌TE13細(xì)胞遷移機(jī)制探討[J]. 中華腫瘤防治雜志  2016  23(13):837-843.

1.  丁妍  王小玲  柳慧 等. Bufalin促進(jìn)人食管癌細(xì)胞ECA109凋亡的研究[J]. 食管外科電子雜志  2014(02):49-54.

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